Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 12/20 | 0.55 |
| ▸ | RARG | P13631 | 11/20 | 0.55 |
| ▸ | RARA | P10276 | 8/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 7/20 | 0.40 |
| ▸ | RXRB | P28702 | 6/20 | 0.40 |
| ▸ | RXRG | P48443 | 4/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23714715 | 1.00 | RARB (0.55) | RARBRARGRARAKDM4EMAPT | |
| SCHEMBL23714891 | 0.79 | RARB (0.55) | RARBRARGRARAKDM4EMAPT | |
| SCHEMBL23714634 | 0.79 | RARB (0.36) | RARBRARGRARAKDM4EMAPT | |
| SCHEMBL23714890 | 0.77 | RARB (0.36) | RARBRARGRARAHSPA9 | |
| SCHEMBL23705405 | 0.77 | KDM1A (0.51) | RARBRARGRARAKDM4EMAPT | |
| SCHEMBL23705297 | 0.73 | RARB (0.54) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL23706054 | 0.73 | RARB (0.54) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL30042835 | 0.73 | RARB (0.54) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL23706073 | 0.73 | RARB (0.54) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL30041725 | 0.73 | RARB (0.54) | RARBRARGRARACYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155320-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |
| WO-2021155316-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |