Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 10/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23716039 | 0.92 | AXL (0.37) | MEN1KMT2AMAPTHDAC1AXL | |
| SCHEMBL23715888 | 0.92 | P2RY12 (0.35) | P2RY12HDAC1AXLEGLN1 | |
| SCHEMBL23702629 | 0.89 | CHRM3 (0.39) | AXL | |
| SCHEMBL30111502 | 0.89 | CHRM3 (0.39) | AXL | |
| SCHEMBL26633249 | 0.89 | CHRM3 (0.39) | AXL | |
| SCHEMBL23715768 | 0.88 | POLB (0.36) | MEN1KMT2AMAPTHDAC1CDC25B | |
| SCHEMBL23702505 | 0.87 | KRAS (0.41) | — | |
| SCHEMBL23702580 | 0.87 | AXL (0.38) | AXL | |
| SCHEMBL30111398 | 0.87 | KRAS (0.41) | — | |
| SCHEMBL23715895 | 0.87 | KRAS (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021152149-A1 | RAS INHIBITORS AND METHODS OF USING THE SAME | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2021-08-05 | — | — | WO | disclosed |