SCHEMBL237188

SCHEMBL237188

C=C(C)C(=O)OCC(C)C(C)(C)O[SiH3]

nearest known ligand 0.56

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.56
THRB P10828 1/20 0.37
ALDH1A1 P00352 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23493794 0.82 TSHR (0.64) TSHRTHRBALDH1A1
SCHEMBL8754872 0.81 TSHR (0.46) TSHRTHRBALDH1A1
SCHEMBL3929660 0.79 TSHR (0.60) TSHRTHRBALDH1A1
SCHEMBL17222398 0.78 TSHR (0.64) TSHRTHRBALDH1A1
Hydrochloric Acid SCHEMBL716522 0.77 TSHR (0.58) TSHRTHRBALDH1A1
SCHEMBL23494172 0.77 TSHR (0.58) TSHRTHRBALDH1A1
Ammonia Solution, Strong SCHEMBL716521 0.77 TSHR (0.58) TSHRTHRBALDH1A1
SCHEMBL21123180 0.77 TSHR (0.62) TSHRTHRBALDH1A1
SCHEMBL236553 0.76 TSHR (0.56) TSHRTHRBALDH1A1
SCHEMBL35271 0.75 TSHR (0.60) TSHRTHRBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2040100-B1 METHOD FOR PRODUCING PHOTOCHROMIC OPTICAL ARTICLE TOKUYAMA CORP (JP) 2019-09-11 EP disclosed
US-9745406-B2 Curable composition CEMEDINE CO., LTD. (JP) 2017-08-29 US disclosed
EP-2412756-B1 CURABLE COMPOSITION CEMEDINE CO LTD (JP) 2016-12-21 EP disclosed
US-20150205020-A1 PROCESS FOR PRODUCING PHOTOCHROMIC OPTICAL ARTICLES TOKUYAMA CORPORATION (JP) 2015-07-23 US disclosed
US-9023424-B2 Process for producing photochromic optical articles TOKUYAMA CORPORATION (JP) 2015-05-05 US disclosed
EP-2412756-A1 CURABLE COMPOSITION CEMEDINE CO., LTD. (JP) 2012-02-01 EP disclosed
US-20120004371-A1 CURABLE COMPOSITION CEMEDINE CO., LTD. (JP) 2012-01-05 US disclosed
US-20090324956-A1 PROCESS FOR PRODUCING PHOTOCHROMIC OPTICAL ARTICLES TOKUYAMA CORPORATION (JP) 2009-12-31 US disclosed
EP-2040100-A1 METHOD FOR PRODUCING PHOTOCHROMIC OPTICAL ARTICLE Tokuyama Corporation (JP) 2009-03-25 EP disclosed