Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 12/20 | 0.52 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29971159 | 1.00 | DPP4 (0.52) | DPP4HSD17B2CYP2C9CYP2C19PDGFRB | |
| SCHEMBL21660272 | 0.87 | MAPT (0.43) | DPP4CYP2C9CYP2C19KDM4EMAPT | |
| SCHEMBL20703109 | 0.84 | CYP2C9 (0.50) | DPP4CYP2C9CYP2C19MAOBMAPT | |
| SCHEMBL26412821 | 0.84 | CYP2C9 (0.50) | DPP4CYP2C9CYP2C19MAOBCA12 | |
| SCHEMBL23714464 | 0.82 | HSD17B2 (0.56) | DPP4HSD17B2CYP2C9CYP2C19PDGFRB | |
| SCHEMBL31023464 | 0.79 | HSD17B2 (0.54) | DPP4HSD17B2CYP2C9CYP2C19PDGFRB | |
| SCHEMBL27393841 | 0.78 | CYP2C9 (0.55) | DPP4HSD17B2CYP2C9CYP2C19PDGFRB | |
| SCHEMBL31527444 | 0.77 | CYP2C9 (0.49) | DPP4HSD17B2CYP2C9CYP2C19PDGFRB | |
| SCHEMBL15350275 | 0.76 | CYP2C9 (0.51) | DPP4HSD17B2CYP2C9CYP2C19PDGFRB | |
| SCHEMBL14466766 | 0.76 | CYP2C9 (0.51) | DPP4CYP2C9CYP2C19MAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230131192-A1 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2023-04-27 | — | — | US | disclosed |
| WO-2021154664-A1 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230131192-A1 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | TLR7, TLR9, TLR1 | DPP4 933/4885HSD17B2 4539/4885CYP2C9 3968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.