Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26414379 | 0.77 | CYP1A2 (0.34) | APPACHE | |
| SCHEMBL23730602 | 0.76 | TSHR (0.39) | PIK3C3 | |
| SCHEMBL25480032 | 0.76 | PIK3C3 (0.38) | PIK3C3 | |
| SCHEMBL24992224 | 0.71 | CD38 (0.33) | PIK3C3 | |
| SCHEMBL23711614 | 0.71 | PIK3C3 (0.40) | PIK3C3 | |
| SCHEMBL23714450 | 0.70 | TLR7 (0.40) | — | |
| SCHEMBL29971101 | 0.69 | TLR7 (0.39) | APPACHE | |
| SCHEMBL30111895 | 0.69 | TLR7 (0.39) | APPACHE | |
| SCHEMBL23704481 | 0.68 | TLR7 (0.44) | — | |
| SCHEMBL23718889 | 0.68 | TLR7 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021154664-A1 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-08-05 | — | — | WO | disclosed |