Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.49 |
| ▸ | GLS | O94925 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HEXA | P06865 | 1/20 | 0.47 |
| ▸ | HEXB | P07686 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26813895 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAHPGDNPSR1RAB9A | |
| SCHEMBL26101354 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAHPGDNPSR1RAB9A | |
| SCHEMBL30274282 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAHPGDNPSR1RAB9A | |
| SCHEMBL30392446 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAHPGDNPSR1RAB9A | |
| SCHEMBL30392640 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAHPGDNPSR1RAB9A | |
| SCHEMBL3892107 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAHPGDNPSR1RAB9A | |
| SCHEMBL19541802 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAHPGDNPSR1RAB9A | |
| SCHEMBL5371487 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAHPGDNPSR1RAB9A | |
| SCHEMBL230525 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAHPGDNPSR1RAB9A | |
| SCHEMBL30274320 | 0.98 | SMN1; SMN2 (0.55) | SMN1; SMN2GAAHPGDNPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4423086-A1 | TYK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2021155006-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES AND USES THEREOF | LES LABORATOIRES SERVIER SAS (FR) | 2021-08-05 | — | — | WO | disclosed |