Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 15/20 | 0.60 |
| ▸ | KDR | P35968 | 15/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | TEK | Q02763 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | FLT1 | P17948 | 12/20 | 0.59 |
| ▸ | CSF1R | P07333 | 2/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30408124 | 0.88 | FLT4 (0.61) | FLT4KDRPDGFRBAURKATEK | |
| SCHEMBL20547607 | 0.88 | FLT4 (0.61) | FLT4KDRPDGFRBAURKATEK | |
| SCHEMBL5501376 | 0.88 | KDR (0.66) | FLT4KDRPDGFRBAURKATEK | |
| SCHEMBL4377465 | 0.87 | KDR (0.65) | FLT4KDRPDGFRBAURKATEK | |
| SCHEMBL20216870 | 0.84 | KDR (0.72) | FLT4KDRPDGFRBFLT1CSF1R | |
| SCHEMBL18676480 | 0.83 | FLT4 (0.69) | FLT4KDRPDGFRBFLT1CSF1R | |
| SCHEMBL23721045 | 0.82 | KDR (0.58) | FLT4KDRPDGFRBFLT1CSF1R | |
| SCHEMBL23158497 | 0.81 | KDM1A (0.68) | FLT4KDRPDGFRBCSF1RFLT3 | |
| SCHEMBL7211076 | 0.81 | KDR (0.66) | FLT4KDRPDGFRBAURKATEK | |
| SCHEMBL4377420 | 0.81 | FLT4 (0.57) | FLT4KDRPDGFRBAURKATEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3615526-B1 | PHENOXYQUINAZOLINE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2021-08-04 | — | — | EP | disclosed |