Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 16/20 | 0.61 |
| ▸ | KDR | P35968 | 16/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.61 |
| ▸ | TEK | Q02763 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | FLT1 | P17948 | 13/20 | 0.58 |
| ▸ | CSF1R | P07333 | 3/20 | 0.57 |
| ▸ | FLT3 | P36888 | 3/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30408124 | 1.00 | FLT4 (0.61) | FLT4KDRPDGFRBTEKAURKB | |
| SCHEMBL29631554 | 0.91 | SRC (0.60) | FLT4KDRPDGFRBTEKAURKB | |
| SCHEMBL5501376 | 0.90 | KDR (0.66) | FLT4KDRPDGFRBTEKAURKB | |
| SCHEMBL4377465 | 0.89 | KDR (0.65) | FLT4KDRPDGFRBTEKAURKB | |
| SCHEMBL23720684 | 0.88 | FLT4 (0.60) | FLT4KDRPDGFRBTEKAURKB | |
| SCHEMBL28343529 | 0.84 | FLT4 (0.53) | FLT4KDRPDGFRBFLT1CSF1R | |
| SCHEMBL20547605 | 0.84 | KDM1A (0.67) | FLT4KDRPDGFRBCSF1RFLT3 | |
| SCHEMBL15084644 | 0.84 | KDM1A (0.67) | FLT4KDRPDGFRBCSF1RFLT3 | |
| SCHEMBL15084643 | 0.84 | KDR (0.59) | FLT4KDRPDGFRBFLT1CSF1R | |
| SCHEMBL2481753 | 0.84 | LCK (0.66) | FLT4KDRPDGFRBTEKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3615526-B1 | PHENOXYQUINAZOLINE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2021-08-04 | — | — | EP | disclosed |
| US-11053223-B2 | Phenoxyquinazoline compounds and their use in treating cancer | ASTRAZENECA AB (SE) | 2021-07-06 | — | — | US | disclosed |
| US-20200223828-A1 | PHENOXYQUINAZOLINE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA UK LIMITED (GB) | 2020-07-16 | — | — | US | disclosed |
| EP-3615526-A1 | PHENOXYQUINAZOLINE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca (SE) | 2020-03-04 | — | — | EP | disclosed |
| WO-2018197643-A1 | PHENOXYQUINAZOLINE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11053223-B2 | Phenoxyquinazoline compounds and their use in treating cancer | KIT, ABL1, RB1 | FLT4 88/4885KDR 30/4885PDGFRB 240/4885 |
| US-20200223828-A1 | PHENOXYQUINAZOLINE COMPOUNDS AND THEIR USE IN TREATING CANCER | KIT, ABL1, RB1 | FLT4 88/4885KDR 30/4885PDGFRB 240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.