Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372112 | 1.00 | BACE1 (0.51) | BACE1CTSD | |
| SCHEMBL2371769 | 0.86 | BACE1 (0.53) | BACE1CTSD | |
| SCHEMBL2371766 | 0.86 | BACE1 (0.53) | BACE1CTSD | |
| SCHEMBL2517996 | 0.83 | BACE1 (0.61) | BACE1CTSD | |
| SCHEMBL2371183 | 0.82 | BACE1 (0.60) | BACE1CTSD | |
| SCHEMBL2522661 | 0.82 | BACE1 (0.52) | BACE1CTSD | |
| SCHEMBL2522657 | 0.82 | BACE1 (0.52) | BACE1CTSD | |
| SCHEMBL2371914 | 0.72 | BACE1 (0.64) | BACE1CTSD | |
| SCHEMBL2371917 | 0.72 | BACE1 (0.64) | BACE1CTSD | |
| SCHEMBL15510348 | 0.72 | BACE1 (0.64) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547685-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |