Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28348597 | 0.84 | TSHR (0.42) | TSHRALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL27352331 | 0.80 | TSHR (0.42) | TSHRALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL5035207 | 0.79 | CYP19A1 (0.42) | TSHRALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL2162474 | 0.79 | GABRA1 (0.42) | TSHRALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL28879999 | 0.79 | CYP19A1 (0.42) | TSHRALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL13971151 | 0.79 | TSHR (0.41) | TSHRALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL25620334 | 0.78 | CYP19A1 (0.41) | TSHRALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL9046583 | 0.77 | TSHR (0.39) | TSHRALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL28553209 | 0.76 | CYP19A1 (0.40) | TSHRALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL4900675 | 0.76 | CYP19A1 (0.40) | TSHRALDH1A1SMN1; SMN2MAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011113756-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-09-22 | — | — | WO | disclosed |
| EP-1549648-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS KINASE INHIBITORS | Celltech R & D Limited (GB) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031188-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2004-04-15 | — | — | WO | disclosed |