Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1194781 | 1.00 | MEN1 (0.46) | MEN1KMT2ABRAFPTGES2MAPT | |
| SCHEMBL827908 | 1.00 | MEN1 (0.46) | MEN1KMT2ABRAFPTGES2MAPT | |
| SCHEMBL1194082 | 1.00 | MEN1 (0.46) | MEN1KMT2ABRAFPTGES2MAPT | |
| SCHEMBL1194779 | 1.00 | MEN1 (0.46) | MEN1KMT2ABRAFPTGES2MAPT | |
| SCHEMBL827907 | 1.00 | MEN1 (0.46) | MEN1KMT2ABRAFPTGES2MAPT | |
| SCHEMBL1194116 | 0.92 | NFE2L2 (0.44) | MEN1KMT2APTGES2MAPTNFE2L2 | |
| SCHEMBL827452 | 0.92 | NFE2L2 (0.44) | MEN1KMT2APTGES2MAPTNFE2L2 | |
| SCHEMBL827453 | 0.92 | NFE2L2 (0.44) | MEN1KMT2APTGES2MAPTNFE2L2 | |
| SCHEMBL1194500 | 0.92 | KMT2A (0.51) | MEN1KMT2AMAPTNFE2L2GPR183 | |
| SCHEMBL1194436 | 0.92 | KMT2A (0.51) | MEN1KMT2AMAPTNFE2L2GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552199-A1 | IMPROVED STABLE AQUEOUS FORMULATION OF (E)-4-CARBOXYSTYRYL-4-CHLOROBENZYL SULFONE | Onconova Therapeutics, Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011119863-A1 | IMPROVED STABLE AQUEOUS FORMULATION OF (E)-4-CARBOXYSTYRYL-4-CHLOROBENZYL SULFONE | ONCONOVA THERAPEUTICS, INC. (US) | 2011-09-29 | — | — | WO | disclosed |