Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LAP3 | P28838 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL178116 | 0.90 | SLC1A3 (0.49) | RCE1HTTKMT2ASLC1A3SLC1A2 | |
| SCHEMBL10720994 | 0.84 | SLC1A3 (0.44) | RCE1HTTKMT2ASLC1A3SLC1A2 | |
| SCHEMBL10718173 | 0.82 | PPARG (0.43) | RCE1HTTKMT2ASLC1A3SLC1A2 | |
| SCHEMBL23998026 | 0.82 | TSHR (0.48) | RCE1HTTKMT2ASLC1A3SLC1A2 | |
| SCHEMBL28017672 | 0.81 | RCE1 (0.43) | RCE1HTTKMT2ASLC1A3SLC1A2 | |
| SCHEMBL16827022 | 0.81 | RCE1 (0.53) | RCE1HTTKMT2ASLC1A3SLC1A2 | |
| SCHEMBL21458529 | 0.81 | RCE1 (0.53) | RCE1HTTKMT2ASLC1A3SLC1A2 | |
| SCHEMBL10720380 | 0.80 | PPARG (0.52) | RCE1TSHRALDH1A1LMNANPC1 | |
| SCHEMBL7155541 | 0.80 | MAPT (0.53) | RCE1HTTKMT2ASLC1A3SLC1A2 | |
| SCHEMBL17663535 | 0.80 | MAPT (0.53) | RCE1HTTKMT2ASLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100124-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Janssen Biotech, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021156787-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2021-08-12 | — | — | WO | disclosed |