Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 12/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 7/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23725134 | 0.81 | CD274 (0.42) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL23725136 | 0.81 | CD274 (0.42) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL23726763 | 0.81 | KDM4E (0.40) | KDM4ENPC1GAARAB9ACD274 | |
| SCHEMBL23726369 | 0.81 | KDM4E (0.55) | KDM4ENPC1GAARAB9ALMNA | |
| SCHEMBL23725967 | 0.76 | MEN1 (0.34) | KDM4ELMNAIRAK4POLBALDH1A1 | |
| SCHEMBL25664635 | 0.73 | IRAK4 (0.33) | IRAK4MAPK1 | |
| SCHEMBL23726160 | 0.73 | KDM4E (0.34) | KDM4ENPC1GAARAB9ALMNA | |
| SCHEMBL23725745 | 0.70 | CD274 (0.38) | CD274PDCD1LG2LMNAPDCD1IRAK4 | |
| SCHEMBL23726597 | 0.70 | CD274 (0.36) | CD274PDCD1LG2PDCD1IRAK4 | |
| SCHEMBL23726277 | 0.69 | PDCD1 (0.52) | CD274PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |