Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 4/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25172225 | 0.82 | DUT (0.32) | — | |
| SCHEMBL23726158 | 0.76 | — | — | |
| SCHEMBL30432879 | 0.74 | SSTR4 (0.32) | — | |
| SCHEMBL23725968 | 0.73 | KDM4E (0.35) | KDM4ERXFP1ALDH1A1NPC1GAA | |
| SCHEMBL3427156 | 0.67 | SMN1; SMN2 (0.63) | LMNAL3MBTL1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL23725956 | 0.66 | KDM4E (0.50) | KDM4EALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL23355599 | 0.63 | BACE1 (0.38) | NPC1RAB9ALMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL20336492 | 0.62 | HRH4 (0.34) | TDP1MEN1KMT2AMAPT | |
| SCHEMBL1143295 | 0.61 | TDP1 (0.49) | ALDH1A1GAATDP1MEN1KMT2A | |
| SCHEMBL1895297 | 0.61 | HTT (0.58) | LMNAL3MBTL1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |