Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 6/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23726247 | 1.00 | NPC1 (0.37) | NPC1RAB9AGAAMAPTATM | |
| SCHEMBL30227786 | 0.87 | HTR2C (0.42) | NPC1RAB9ANAAAAGTR2SMN1; SMN2 | |
| SCHEMBL6062325 | 0.83 | KLK7 (0.38) | NAAA | |
| SCHEMBL23726864 | 0.77 | NPC1 (0.37) | NPC1RAB9AMAPTL3MBTL1CRBN | |
| SCHEMBL30227859 | 0.77 | ALDH1A1 (0.41) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL21829775 | 0.74 | HTR2C (0.44) | NPC1RAB9ANAAAAGTR2SMN1; SMN2 | |
| SCHEMBL23726468 | 0.72 | FASN (0.41) | NPC1RAB9AMAPTNAAASMN1; SMN2 | |
| SCHEMBL23726130 | 0.71 | MME (0.32) | — | |
| SCHEMBL8196059 | 0.70 | PSEN1 (0.53) | NPC1RAB9ANAAAAGTR2SMN1; SMN2 | |
| SCHEMBL8654851 | 0.70 | PSEN1 (0.53) | NPC1RAB9ANAAAAGTR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658667-A1 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY | Merck Sharp & Dohme LLC (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163691-A1 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY | MERCK SHARP & DOHME LLC (US) | 2024-08-08 | — | — | WO | disclosed |
| WO-2021158781-A1 | METHODS FOR PRACTICAL SYNTHESIS OF DEUTERATED AMINO ACIDS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-08-12 | — | — | WO | disclosed |