Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL112468 | 0.85 | MAPT (0.78) | MAPTGAAKDM4EALDH1A1TSHR | |
| SCHEMBL31095359 | 0.85 | MAPT (0.78) | MAPTGAAKDM4EALDH1A1TSHR | |
| SCHEMBL7325807 | 0.85 | ALDH1A1 (0.50) | MAPTGAAKDM4EALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL10607534 | 0.83 | ALDH1A1 (0.53) | MAPTGAAKDM4EALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL4945295 | 0.83 | MAPT (0.81) | MAPTGAAKDM4EALDH1A1TSHR | |
| SCHEMBL1159205 | 0.79 | GAA (0.96) | MAPTGAAKDM4EALDH1A1TSHR | |
| SCHEMBL1010304 | 0.79 | KDM4E (0.50) | MAPTGAAKDM4EALDH1A1TSHR | |
| SCHEMBL10238812 | 0.78 | GAA (0.58) | MAPTGAAKDM4EALDH1A1TSHR | |
| SCHEMBL3317051 | 0.77 | GAA (0.57) | MAPTGAAKDM4EALDH1A1TSHR | |
| SCHEMBL27547295 | 0.77 | MAPT (0.67) | MAPTGAAKDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |