Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257194 | 0.83 | ALDH1A1 (0.50) | PTGS1PTGS2KMT2AKDM4EGLA | |
| SCHEMBL8247383 | 0.77 | KDM4E (0.48) | PTGS1PTGS2KMT2AKDM4EGLA | |
| SCHEMBL22499335 | 0.77 | KDM4E (0.57) | PTGS1PTGS2KMT2AKDM4EGLA | |
| Hydrochloric Acid SCHEMBL22499322 | 0.75 | KDM4E (0.56) | PTGS1PTGS2KMT2AKDM4EGLA | |
| SCHEMBL8253920 | 0.75 | KDM4E (0.40) | PTGS1PTGS2KMT2AKDM4EGLA | |
| SCHEMBL119926 | 0.75 | GAA (0.66) | PTGS1PTGS2KMT2AKDM4EGAA | |
| SCHEMBL21893768 | 0.74 | KDM4E (0.43) | KMT2AKDM4EGLAGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL31014617 | 0.74 | PTGS1 (0.51) | PTGS1PTGS2KMT2AKDM4EGLA | |
| SCHEMBL13162050 | 0.72 | PTGS1 (0.39) | PTGS1PTGS2KMT2AKDM4EGLA | |
| SCHEMBL20851163 | 0.72 | ALDH1A1 (0.41) | KMT2AKDM4EGLAGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100004-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158634-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |