Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28650156 | 0.86 | FGFR4 (0.44) | TGFBR1KDM4EGAATSHRSMN1; SMN2 | |
| SCHEMBL23728493 | 0.81 | TGFBR1 (0.48) | TGFBR1KDM4ETSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL461457 | 0.77 | TGFBR1 (0.42) | TGFBR1KDM4ESMN1; SMN2L3MBTL1CAMKK1 | |
| SCHEMBL461050 | 0.76 | FLT3 (0.44) | TGFBR1KDM4ESMN1; SMN2L3MBTL1DHODH | |
| SCHEMBL359281 | 0.76 | TYK2 (0.53) | TGFBR1KDM4EL3MBTL1TYK2IRAK4 | |
| SCHEMBL405711 | 0.76 | JAK2 (0.48) | TGFBR1TYK2 | |
| SCHEMBL23744412 | 0.73 | JAK2 (0.41) | TGFBR1L3MBTL1CAMKK1CAMKK2IRAK4 | |
| SCHEMBL16935961 | 0.73 | NTRK1 (0.38) | TGFBR1STING1 | |
| SCHEMBL16935963 | 0.73 | NTRK1 (0.38) | TGFBR1STING1 | |
| SCHEMBL23728447 | 0.72 | KDM4E (0.49) | TGFBR1KDM4EL3MBTL1CAMKK1CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100004-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158634-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |