Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 4/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17048744 | 0.87 | KMT2A (0.37) | GAAEPHX1BTKKMT2AMEN1 | |
| SCHEMBL17048739 | 0.87 | KMT2A (0.37) | GAAEPHX1BTKKMT2AMEN1 | |
| SCHEMBL17048742 | 0.87 | KMT2A (0.37) | GAAEPHX1BTKKMT2AMEN1 | |
| SCHEMBL3327036 | 0.82 | BTK (0.46) | GAAEPHX1BTKKMT2AL3MBTL1 | |
| SCHEMBL3326571 | 0.82 | BTK (0.46) | GAAEPHX1BTKKMT2AL3MBTL1 | |
| SCHEMBL14169680 | 0.82 | BTK (0.46) | GAAEPHX1BTKKMT2AL3MBTL1 | |
| SCHEMBL15600327 | 0.80 | GAA (0.44) | GAAEPHX1BTKKMT2AMEN1 | |
| SCHEMBL2074992 | 0.79 | GAA (0.51) | GAAEPHX1BTKKMT2AMEN1 | |
| SCHEMBL6344084 | 0.79 | GAA (0.43) | GAAEPHX1BTKKMT2AMEN1 | |
| SCHEMBL31168732 | 0.79 | GAA (0.43) | GAAEPHX1BTKKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100004-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158634-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |