Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17048744 | 1.00 | KMT2A (0.37) | KMT2AMEN1ALDH1A1TSHRGAA | |
| SCHEMBL17048742 | 1.00 | KMT2A (0.37) | KMT2AMEN1ALDH1A1TSHRGAA | |
| SCHEMBL23728544 | 0.87 | GAA (0.40) | KMT2AMEN1ALDH1A1TSHRGAA | |
| SCHEMBL17098204 | 0.85 | LMNA (0.37) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL17098201 | 0.85 | LMNA (0.37) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL17098208 | 0.85 | LMNA (0.37) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL17048990 | 0.79 | KMT2A (0.36) | KMT2AMEN1ALDH1A1TSHRGAA | |
| SCHEMBL25979754 | 0.77 | KMT2A (0.39) | KMT2AMEN1ALDH1A1TSHRGAA | |
| SCHEMBL15600327 | 0.76 | GAA (0.44) | KMT2AMEN1GAABTKMAPK1 | |
| SCHEMBL168732 | 0.76 | KMT2A (0.54) | KMT2AMEN1ALDH1A1TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3110810-B1 | PYRAZOLE AMIDE DERIVATIVE | TEIJIN PHARMA LTD (JP) | 2018-05-02 | — | — | EP | disclosed |
| EP-3110810-A1 | PYRAZOLE AMIDE DERIVATIVE | Teijin Pharma Limited (JP) | 2017-01-04 | — | — | EP | disclosed |
| WO-2015129926-A1 | PYRAZOLE AMIDE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2015-09-03 | — | — | WO | disclosed |