SCHEMBL2372935 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	TRPV4	Q9HBA0	18/20	0.40

▸	TACR2	P21452	1/20	0.38

▸	TACR3	P29371	1/20	0.38

▸	KCNH2	Q12809	1/20	0.38

▸	CACNA1C	Q13936	1/20	0.38

▸	SCN5A	Q14524	1/20	0.38

▸	CASP6	P55212	1/20	0.37

▸	NR1I2	O75469	1/20	0.36

▸	MAPK13	O15264	1/20	0.35

▸	MAPK9	P45984	1/20	0.35

▸	MAPK12	P53778	1/20	0.35

▸	MAPK11	Q15759	1/20	0.35

▸	MAPK14	Q16539	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2373361	0.92	TRPV4 (0.38)	TRPV4TACR2TACR3KCNH2CACNA1C
SCHEMBL2373052	0.92	TRPV4 (0.38)	TRPV4TACR2TACR3KCNH2CACNA1C
SCHEMBL2373297	0.91	TRPV4 (0.39)	TRPV4TACR2TACR3KCNH2CACNA1C
SCHEMBL2373237	0.89	TRPV4 (0.49)	TRPV4TACR2TACR3KCNH2CACNA1C
SCHEMBL2372782	0.88	TRPV4 (0.47)	TRPV4TACR2TACR3KCNH2CACNA1C
SCHEMBL2372456	0.88	TRPV4 (0.48)	TRPV4TACR2TACR3KCNH2CACNA1C
SCHEMBL2373078	0.85	TRPV4 (0.42)	TRPV4TACR2TACR3KCNH2CACNA1C
SCHEMBL2373082	0.85	TRPV4 (0.47)	TRPV4TACR2TACR3KCNH2CACNA1C
SCHEMBL2372735	0.85	TRPV4 (0.43)	TRPV4TACR2TACR3KCNH2CACNA1C
SCHEMBL2372101	0.85	TRPV4 (0.52)	TRPV4TACR2TACR3KCNH2CACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011119704-A1	TRPV4 ANTAGONISTS	GLAXOSMITHKLINE LLC (US)	2011-09-29	—	—	WO	disclosed