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Sugi Predict / Compounds / SCHEMBL2373155

SCHEMBL2373155

SCHEMBL2373155

COC(=O)c1c(C)c(-c2cccc(C(F)(F)F)c2)nc2ccc(S(=O)(=O)N(C)C)cc12

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ DHODH Q02127 9/20 0.52
▸ PTGFR P43088 9/20 0.46
▸ MMP1 P03956 1/20 0.42
▸ MMP9 P14780 1/20 0.42
▸ MMP13 P45452 1/20 0.42
▸ ADAM17 P78536 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2373180 0.90 DHODH (0.54) DHODHPTGFRKDM4EMEN1KMT2A
SCHEMBL2372133 0.90 DHODH (0.54) DHODHPTGFRKDM4EMEN1KMT2A
SCHEMBL2464452 0.87 DHODH (0.52) DHODHPTGFRKDM4EMEN1KMT2A
SCHEMBL2372070 0.86 DHODH (0.65) DHODHPTGFRKDM4EMEN1KMT2A
SCHEMBL2371993 0.85 DHODH (0.59) DHODHPTGFRKDM4EMEN1KMT2A
SCHEMBL14553163 0.85 DHODH (0.59) DHODHPTGFRKDM4EMEN1KMT2A
SCHEMBL2461722 0.84 DHODH (0.73) DHODHPTGFR
SCHEMBL2372745 0.84 PTGFR (0.61) DHODHPTGFRKDM4EMEN1KMT2A
SCHEMBL2373435 0.83 DHODH (0.57) DHODHPTGFRKDM4EMAPT
SCHEMBL2373029 0.83 DHODH (0.57) DHODHPTGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011119693-A1 TRPV4 ANTAGONISTS GLAXOSMITHKLINE LLC (US) 2011-09-29 — — WO disclosed