Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.57 |
| ▸ | PTGFR | P43088 | 12/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373573 | 0.93 | PTGFR (0.56) | DHODHPTGFR | |
| SCHEMBL2406597 | 0.93 | DHODH (0.50) | DHODHPTGFRPLA2G2AMITF | |
| SCHEMBL2372822 | 0.92 | DHODH (0.49) | DHODHPTGFRPLGPLAUPLAT | |
| SCHEMBL2372797 | 0.92 | DHODH (0.66) | DHODHPTGFR | |
| SCHEMBL2372070 | 0.92 | DHODH (0.65) | DHODHPTGFR | |
| SCHEMBL2372055 | 0.91 | DHODH (0.54) | DHODHPTGFR | |
| SCHEMBL2372609 | 0.90 | DHODH (0.53) | DHODHPTGFR | |
| SCHEMBL2371993 | 0.90 | DHODH (0.59) | DHODHPTGFR | |
| SCHEMBL14553163 | 0.90 | DHODH (0.59) | DHODHPTGFR | |
| SCHEMBL2461722 | 0.89 | DHODH (0.73) | DHODHPTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |