Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9886089 | 0.86 | TAAR1 (0.50) | TAAR1POLBGAAGFERP2RX3 | |
| SCHEMBL13351579 | 0.83 | TAAR1 (0.55) | TAAR1POLBGAAGFERP2RX3 | |
| SCHEMBL13618030 | 0.81 | TAAR1 (0.53) | TAAR1MTNR1AMTNR1B | |
| SCHEMBL12190521 | 0.81 | GAA (0.50) | POLBGAAGFERP2RX3P2RX2 | |
| SCHEMBL12425507 | 0.80 | POLB (0.56) | TAAR1POLBGAAGFERP2RX3 | |
| SCHEMBL17862081 | 0.79 | TAAR1 (0.59) | TAAR1POLBGAAGFERP2RX3 | |
| SCHEMBL13059718 | 0.79 | GAA (0.48) | POLBGAAGFERP2RX3P2RX2 | |
| SCHEMBL11919300 | 0.79 | TAAR1 (0.47) | TAAR1MTNR1AMTNR1BP2RX7 | |
| SCHEMBL12896237 | 0.79 | DPP4 (0.38) | — | |
| SCHEMBL22019566 | 0.79 | TAAR1 (0.50) | TAAR1POLBGAAGFERP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021154661-A1 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-08-05 | — | — | WO | disclosed |