Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.64 |
| ▸ | PDE1A | P54750 | 4/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.59 |
| ▸ | PDE6A | P16499 | 3/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.59 |
| ▸ | PDE2A | O00408 | 2/20 | 0.59 |
| ▸ | PDE6D | O43924 | 2/20 | 0.59 |
| ▸ | PDE9A | O76083 | 2/20 | 0.59 |
| ▸ | PDE6G | P18545 | 2/20 | 0.59 |
| ▸ | PDE4A | P27815 | 2/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | PDE6B | P35913 | 2/20 | 0.59 |
| ▸ | PDE6C | P51160 | 2/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18539070 | 0.94 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL23937275 | 0.93 | PDE5A (0.65) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL6641779 | 0.87 | PDE5A (0.81) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL28531067 | 0.87 | PDE5A (0.60) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL19254528 | 0.86 | PDE5A (0.78) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL6529760 | 0.82 | PDE5A (0.84) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL23923868 | 0.82 | PDE5A (0.68) | PDE5A | |
| Mirodenafil SCHEMBL15481149 | 0.82 | PDE5A (0.80) | PDE5APDE1APDE1BPDE1CPDE3B | |
| Hydrochloric Acid SCHEMBL6641810 | 0.82 | PDE5A (0.82) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL6486204 | 0.81 | PDE5A (0.79) | PDE5APDE1APDE1BPDE1CPDE6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210236504-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER PATIENT STRATIFICATION AND CANCER TREATMENT | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210236504-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER PATIENT STRATIFICATION AND CANCER TREATMENT | CREB1, CREBBP, SLFN12 | PDE5A 6/4885PDE1A 129/4885PDE1B 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.