CREB1

Cyclic AMP-responsive element-binding protein 1 · P16220 · CREB1 on Sugi Atlas →

873 patent compounds predicted against CREB1, 671 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Baicalein (SCHEMBL139617)	1.00	6/20
Oroxylin A (SCHEMBL431423)	1.00	6/20
SCHEMBL970349	1.00	6/20
SCHEMBL971995	1.00	6/20
SCHEMBL972407	1.00	6/20
SCHEMBL972514	1.00	6/20
Baicalein (SCHEMBL5695785)	1.00	6/20
Baicalein (SCHEMBL29385549)	1.00	6/20
Baicalein (SCHEMBL2420136)	0.97	6/20
Baicalein (SCHEMBL28087999)	0.97	6/20
Baicalein (SCHEMBL28198926)	0.97	6/20
Baicalein (SCHEMBL28206740)	0.97	6/20
Baicalein (SCHEMBL28372093)	0.97	6/20
Baicalein (SCHEMBL28630648)	0.97	6/20
Baicalein (SCHEMBL28826034)	0.97	6/20
Baicalein (SCHEMBL28365951)	0.94	6/20
Baicalein (SCHEMBL28567725)	0.94	6/20
Baicalein (SCHEMBL28132467)	0.89	6/20
Baicalein (SCHEMBL29200768)	0.89	6/20
Baicalein (SCHEMBL28504707)	0.86	6/20

Clinical trials — most relevant to CREB1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room	PHASE2/PHASE3	COMPLETED
Preoperative Glucocorticoid Use in Major Hepatectomy	PHASE2/PHASE3	COMPLETED
Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus.	PHASE3	COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Metformin for Fibromyalgia Symptoms (INFORM Trial)	PHASE2	RECRUITING
Rapid Antidepressant Effects of Yohimbine in Major Depression	PHASE2	COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction	PHASE2	ACTIVE_NOT_RECRUITING
Immunomodulating Therapy and Improved Vaccination Responses by Cox-2 Inhibitor in HIV-infected Patients	PHASE2	COMPLETED
Safety Study of the Effect of Scelectium Tortuosum (as Zembrin®)in Aged Normals	PHASE1	COMPLETED
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.	PHASE1	COMPLETED
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients	PHASE1	COMPLETED
IGF and Other Neurotrophic Factors in Patients With Dementia	nan	COMPLETED
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder.	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Effect of Exercise Gene Expression and Histone Modifications in Patients With Hemiplegia	nan	RECRUITING
Evaluation the Topical Apremilast Nanoformulation in Treatment of Localized Plaque Psoriasis	nan	NOT_YET_RECRUITING
Nasturtium (Tropaeolum Majus L) Intake and Biochemical Parameters in Pre-diabetic Subjects in Bogota Colombia	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Exercise Effects on Cardiometabolic Health and Sestrin-2 in Hypertensive Obese Women	nan	NOT_YET_RECRUITING
Immune Interactions in Severe Asthma	nan	COMPLETED
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load	nan	COMPLETED
Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CREB1 binder may also engage these)

Protein	Name	Similarity
Q01147	—	1.000	Q01147 →
P27925	—	1.000	P27925 →
P15337	—	1.000	P15337 →
Q08DA8	—	1.000	Q08DA8 →
Q03061	—	0.997	Q03061 →
ATF1	Cyclic AMP-dependent transcription factor ATF-1	0.996	landscape →
Q1LZH5	—	0.994	Q1LZH5 →
Q62445	—	0.994	Q62445 →
P81269	—	0.994	P81269 →
O08949	—	0.993	O08949 →
P79145	—	0.993	P79145 →
Q5RCU0	—	0.993	Q5RCU0 →
Q5E9U0	—	0.992	Q5E9U0 →
Q8TAK5	—	0.991	Q8TAK5 →
Q06547	—	0.991	Q06547 →
Q4VYS1	—	0.990	Q4VYS1 →
Q90WR8	—	0.989	Q90WR8 →
Q498D1	—	0.989	Q498D1 →
P16143	—	0.989	P16143 →
Q00420	—	0.988	Q00420 →
P70353	—	0.988	P70353 →
P27699	—	0.988	P27699 →
Q03060	—	0.987	Q03060 →
Q5R6A9	—	0.987	Q5R6A9 →
O94842	—	0.987	O94842 →
P52655	—	0.987	P52655 →
B5DE69	—	0.987	B5DE69 →
Q8MJA0	—	0.987	Q8MJA0 →
P58463	—	0.987	P58463 →
Q2HJ84	—	0.987	Q2HJ84 →