Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.59 |
| ▸ | SRC | P12931 | 3/20 | 0.59 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.51 |
| ▸ | BCR | P11274 | 5/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | EIF4E | P06730 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | ABL2 | P42684 | 6/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19307236 | 0.91 | ABL1 (0.70) | ABL1SRCRETKDRABL2 | |
| SCHEMBL29614757 | 0.91 | ABL1 (0.70) | ABL1SRCRETKDRABL2 | |
| SCHEMBL23732816 | 0.86 | ABL1 (0.53) | ABL1MKNK1MKNK2BCRRET | |
| SCHEMBL23732817 | 0.84 | ABL1 (0.47) | ABL1SRCMKNK1MKNK2BCR | |
| SCHEMBL29614760 | 0.80 | ABL1 (0.60) | ABL1SRCRETKITKDR | |
| SCHEMBL19307227 | 0.80 | ABL1 (0.60) | ABL1SRCRETKITKDR | |
| SCHEMBL29614711 | 0.79 | ABL1 (0.63) | ABL1SRCRETKDRABL2 | |
| SCHEMBL19307185 | 0.79 | ABL1 (0.63) | ABL1SRCRETKDRABL2 | |
| SCHEMBL20214661 | 0.78 | ABL1 (0.46) | ABL1SRCMKNK2BCRRET | |
| SCHEMBL29614794 | 0.77 | ABL1 (0.62) | ABL1SRCRETKDRABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238167-A1 | SMALL MOLECULE IRE1-ALPHA INHIBITORS | CORNELL UNIVERSITY | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238167-A1 | SMALL MOLECULE IRE1-ALPHA INHIBITORS | XBP1, ERN1, ERN2 | ABL1 3753/4885SRC 4035/4885MKNK1 529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.