Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.53 |
| ▸ | ABL2 | P42684 | 6/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.52 |
| ▸ | BCR | P11274 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | EIF4E | P06730 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19307164 | 0.91 | ABL1 (0.65) | ABL1ABL2RETKDRNTRK1 | |
| SCHEMBL29614931 | 0.91 | ABL1 (0.65) | ABL1ABL2RETKDRNTRK1 | |
| SCHEMBL19307233 | 0.89 | ABL1 (0.49) | ABL1ABL2MKNK1MKNK2BCR | |
| SCHEMBL29614814 | 0.89 | ABL1 (0.49) | ABL1ABL2MKNK1MKNK2BCR | |
| SCHEMBL23732815 | 0.86 | ABL1 (0.59) | ABL1ABL2MKNK1MKNK2BCR | |
| SCHEMBL19307131 | 0.86 | ABL1 (0.51) | ABL1ABL2MKNK1MKNK2BCR | |
| SCHEMBL29614800 | 0.86 | ABL1 (0.51) | ABL1ABL2MKNK1MKNK2BCR | |
| SCHEMBL23732817 | 0.84 | ABL1 (0.47) | ABL1ABL2MKNK1MKNK2BCR | |
| SCHEMBL24448260 | 0.81 | ABL1 (0.73) | ABL1ABL2KITRETKDR | |
| SCHEMBL19316719 | 0.80 | ABL1 (0.55) | ABL1ABL2KITKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238167-A1 | SMALL MOLECULE IRE1-ALPHA INHIBITORS | CORNELL UNIVERSITY | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238167-A1 | SMALL MOLECULE IRE1-ALPHA INHIBITORS | XBP1, ERN1, ERN2 | ABL1 3753/4885ABL2 4577/4885MKNK1 529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.