Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DCK | P27707 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 5/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23478902 | 0.81 | MAPT (0.42) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12231721 | 0.77 | HSD17B1 (0.42) | MAPTRAB9ASMN1; SMN2HSD17B1HSD17B2 | |
| SCHEMBL22946430 | 0.77 | ESR1 (0.44) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22053196 | 0.75 | KDM4E (0.48) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22789695 | 0.71 | HSD17B1 (0.41) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13361743 | 0.68 | ESR1 (0.40) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15886302 | 0.67 | PIK3CD (0.37) | — | |
| SCHEMBL17226334 | 0.67 | PTPN1 (0.56) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2244394 | 0.67 | CCR1 (0.40) | MAPTNPC1RAB9ASMN1; SMN2ESR1 | |
| SCHEMBL2245501 | 0.67 | CCR1 (0.40) | KDM4EMAPTNPC1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278628-A1 | HUMAN PLACENTAL HEMATOPOIETIC STEM CELL DERIVED NATURAL KILLER CELLS IN ACUTE MYELOID LEUKEMIA (AML) REMISSION WITH MINIMAL RESIDUAL DISEASE (MRD) OR RELAPSED/REFRACTORY AML | CELULARITY INC. (US) | 2023-01-05 | — | — | WO | disclosed |
| WO-2021155312-A1 | PLACENTAL DERIVED NATURAL KILLER CELLS FOR TREATMENT OF CORONAVIRUS INFECTIONS | CELULARITY INC. (US) | 2021-08-05 | — | — | WO | disclosed |