Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 20/20 | 0.79 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.74 |
| ▸ | TACR2 | P21452 | 1/20 | 0.67 |
| ▸ | TACR3 | P29371 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.67 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6891018 | 1.00 | TRPV4 (0.79) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL17268049 | 0.91 | TRPV4 (0.73) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL2373905 | 0.91 | TRPV4 (0.81) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL17268113 | 0.88 | TRPV4 (0.80) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL17268038 | 0.87 | TRPV4 (0.79) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL6899835 | 0.87 | TRPV4 (0.79) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL2373139 | 0.87 | TRPV4 (0.79) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL17268134 | 0.87 | TRPV4 (0.73) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL17268037 | 0.87 | TRPV4 (0.69) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL2374143 | 0.86 | TRPV4 (0.75) | TRPV4NR1I2TACR2TACR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | claimed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |