Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 5/20 | 0.65 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2610311 | 0.88 | MGLL (0.57) | KHKPLA2G10FGFR1MGLLNPC1 | |
| SCHEMBL3668866 | 0.83 | PLA2G10 (0.67) | KHKPLA2G10MGLLNPC1HSP90AA1 | |
| SCHEMBL31279982 | 0.80 | KHK (1.00) | KHKMGLLMAPK1HPGDS | |
| SCHEMBL23711723 | 0.80 | KHK (1.00) | KHKMGLLMAPK1HPGDS | |
| SCHEMBL1667310 | 0.79 | PLA2G10 (0.55) | KHKPLA2G10MGLLNPC1HSP90AA1 | |
| SCHEMBL31279611 | 0.78 | KHK (1.00) | KHKHPGDS | |
| SCHEMBL23711737 | 0.78 | KHK (1.00) | KHKHPGDS | |
| SCHEMBL30040852 | 0.76 | SMO (0.49) | KHKPLA2G10MGLLMAPK1 | |
| SCHEMBL19533612 | 0.76 | MGLL (0.55) | KHKPLA2G10FGFR1MGLLNPC1 | |
| SCHEMBL9986667 | 0.76 | SMO (0.49) | KHKPLA2G10MGLLMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11083720-B2 | Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases | REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11083720-B2 | Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases | KHK, GCK, HK1 | KHK 1/4885PLA2G10 4763/4885FGFR1 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.