Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.37 |
| ▸ | HTR6 | P50406 | 5/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19684784 | 0.84 | PNMT (0.40) | PNMTHTR6PARP1 | |
| SCHEMBL19711557 | 0.82 | PNMT (0.39) | PNMTHTR6ADRA2AADRA2BADRA2C | |
| SCHEMBL19710968 | 0.80 | PNMT (0.35) | PNMTHTR6ADRA2AADRA2BADRA2C | |
| SCHEMBL19711571 | 0.79 | PNMT (0.49) | PNMTHTR6ADRA2AADRA2BADRA2C | |
| SCHEMBL19710976 | 0.79 | PNMT (0.37) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL19710964 | 0.79 | HTR2A (0.41) | PNMTHTR6ADRA2AADRA2BADRA2C | |
| SCHEMBL19710972 | 0.78 | PNMT (0.33) | PNMTHTR2AHTR2C | |
| SCHEMBL23735224 | 0.77 | HTR2C (0.35) | PNMTHTR6ADRA2AADRA2BADRA2C | |
| SCHEMBL20778128 | 0.77 | PNMT (0.35) | PNMTHTR6PARP1 | |
| SCHEMBL19678859 | 0.77 | HTR2A (0.35) | PNMTHTR6HTR2AHTR2CPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464249-B1 | SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER (US) | 2021-08-11 | — | — | EP | disclosed |