SCHEMBL23735302

SCHEMBL23735302

NNC(O)C1CCCC(NC(=O)c2cccc(Cl)c2)C1

nearest known ligand 0.73

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 18/20 0.73
L3MBTL1 Q9Y468 1/20 0.64
NPC1 O15118 1/20 0.63
RAB9A P51151 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19797893 0.81 GRM5 (0.76) GRM5L3MBTL1NPC1RAB9A
SCHEMBL19797894 0.81 GRM5 (0.76) GRM5L3MBTL1NPC1RAB9A
SCHEMBL19797902 0.81 GRM5 (0.80) GRM5L3MBTL1NPC1RAB9A
SCHEMBL19797900 0.81 GRM5 (0.80) GRM5L3MBTL1NPC1RAB9A
SCHEMBL15326419 0.79 L3MBTL1 (1.00) GRM5L3MBTL1NPC1RAB9A
SCHEMBL15323778 0.78 NPC1 (1.00) GRM5L3MBTL1NPC1RAB9A
SCHEMBL28975696 0.77 L3MBTL1 (0.88) GRM5L3MBTL1NPC1RAB9A
SCHEMBL19797860 0.76 GRM5 (0.76) GRM5L3MBTL1NPC1RAB9A
SCHEMBL23716717 0.76 GRM5 (0.76) GRM5L3MBTL1NPC1RAB9A
SCHEMBL19797859 0.76 GRM5 (0.76) GRM5L3MBTL1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3487840-B1 CYCLOHEXYL BENZAMIDE COMPOUNDS LILLY CO ELI (US) 2021-08-11 EP disclosed