SCHEMBL23735330

SCHEMBL23735330

Cc1ncnc2c1c(F)cn2I

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 1/20 0.32
WDR77 Q9BQA1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19684528 0.79 EIF2AK3 (0.34) PRMT5WDR77
SCHEMBL19711584 0.79 ADORA2A (0.37) PRMT5WDR77
SCHEMBL18055946 0.78 DYRK1A (0.39) PRMT5WDR77
SCHEMBL26084925 0.77 PRMT5 (0.30) PRMT5WDR77
SCHEMBL20778077 0.76 ADORA2A (0.40) PRMT5WDR77
SCHEMBL19684532 0.75 SRC (0.44)
SCHEMBL26357318 0.75 PIK3CD (0.37)
SCHEMBL19375816 0.68 ADK (0.30)
SCHEMBL23735270 0.67 ADK (0.47)
SCHEMBL11927547 0.63 ADK (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3464249-B1 SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS PFIZER (US) 2021-08-11 EP disclosed