SCHEMBL2373547 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	TRPV4	Q9HBA0	16/20	0.41

▸	NR1I2	O75469	1/20	0.37

▸	TACR2	P21452	1/20	0.37

▸	TACR3	P29371	1/20	0.37

▸	KCNH2	Q12809	1/20	0.37

▸	CACNA1C	Q13936	1/20	0.37

▸	SCN5A	Q14524	1/20	0.37

▸	CTSA	P10619	1/20	0.36

▸	ADRA1D	P25100	1/20	0.36

▸	ADRA1A	P35348	1/20	0.36

▸	ADRA1B	P35368	1/20	0.36

▸	PGK1	P00558	1/20	0.36

▸	CASP6	P55212	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2373460	0.98	TRPV4 (0.42)	TRPV4NR1I2TACR2TACR3KCNH2
SCHEMBL2373123	0.92	TRPV4 (0.41)	TRPV4NR1I2TACR2TACR3KCNH2
SCHEMBL2371704	0.92	TRPV4 (0.43)	TRPV4NR1I2TACR2TACR3KCNH2
SCHEMBL2372627	0.91	TRPV4 (0.43)	TRPV4NR1I2TACR2TACR3KCNH2
SCHEMBL2373030	0.91	TRPV4 (0.41)	TRPV4NR1I2TACR2TACR3KCNH2
SCHEMBL2373462	0.91	TRPV4 (0.41)	TRPV4NR1I2TACR2TACR3KCNH2
SCHEMBL2373151	0.91	TRPV4 (0.40)	TRPV4NR1I2TACR2TACR3KCNH2
SCHEMBL2373459	0.89	TRPV4 (0.44)	TRPV4NR1I2TACR2TACR3KCNH2
SCHEMBL2373082	0.89	TRPV4 (0.47)	TRPV4NR1I2TACR2TACR3KCNH2
SCHEMBL2372101	0.89	TRPV4 (0.52)	TRPV4NR1I2TACR2TACR3KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011119693-A1	TRPV4 ANTAGONISTS	GLAXOSMITHKLINE LLC (US)	2011-09-29	—	—	WO	disclosed