Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170562 | 0.87 | — | — | |
| SCHEMBL3682172 | 0.86 | ANPEP (0.32) | MMP8MMP1 | |
| SCHEMBL19079580 | 0.86 | ANPEP (0.32) | MMP8MMP1 | |
| SCHEMBL21703658 | 0.86 | ANPEP (0.32) | MMP8MMP1 | |
| SCHEMBL20118074 | 0.86 | ANPEP (0.32) | MMP8MMP1 | |
| SCHEMBL19079578 | 0.86 | ANPEP (0.32) | MMP8MMP1 | |
| SCHEMBL19079575 | 0.86 | ANPEP (0.32) | MMP8MMP1 | |
| SCHEMBL19079579 | 0.86 | ANPEP (0.32) | MMP8MMP1 | |
| SCHEMBL102088 | 0.85 | CPB2 (0.33) | MMP8MMP1 | |
| SCHEMBL105388 | 0.85 | CPB2 (0.33) | MMP8MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4001269-A1 | BENZOISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | Amgen Inc. (US) | 2022-05-25 | — | — | EP | disclosed |
| EP-3558955-B1 | BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | AMGEN INC (US) | 2021-08-11 | — | — | EP | disclosed |