Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20334401 | 0.81 | MEN1 (0.38) | MEN1FAAHMAPK1KMT2A | |
| SCHEMBL20326229 | 0.80 | MEN1 (0.33) | MEN1FAAHMAPK1KMT2A | |
| SCHEMBL20326290 | 0.79 | MEN1 (0.40) | MEN1FAAHMAPK1KMT2A | |
| SCHEMBL24481376 | 0.77 | MEN1 (0.32) | MEN1FAAHMAPK1KMT2A | |
| SCHEMBL20327123 | 0.75 | MEN1 (0.30) | MEN1FAAHMAPK1KMT2A | |
| SCHEMBL21794887 | 0.73 | — | — | |
| SCHEMBL23735865 | 0.73 | — | — | |
| SCHEMBL23475900 | 0.72 | MEN1 (0.43) | MEN1FAAHMAPK1KMT2A | |
| SCHEMBL25854550 | 0.72 | F2 (0.43) | MEN1FAAHMAPK1KMT2A | |
| SCHEMBL20327092 | 0.72 | CTSK (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558955-B1 | BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | AMGEN INC (US) | 2021-08-11 | — | — | EP | disclosed |