Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 16/20 | 0.61 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870192 | 0.85 | EIF2AK3 (0.61) | EIF2AK3EIF2AK1NPC1MAPTRAB9A | |
| SCHEMBL27975489 | 0.84 | EIF2AK3 (0.67) | EIF2AK3EIF2AK1KDR | |
| SCHEMBL2373042 | 0.84 | EIF2AK3 (0.43) | EIF2AK3EIF2AK1NPC1ALDH1A1MAPT | |
| SCHEMBL868669 | 0.83 | EIF2AK3 (0.68) | EIF2AK3EIF2AK1KDR | |
| SCHEMBL2375097 | 0.83 | EIF2AK3 (0.65) | EIF2AK3EIF2AK1NPC1ALDH1A1MAPT | |
| SCHEMBL2374288 | 0.82 | EIF2AK3 (0.45) | EIF2AK3EIF2AK1ALDH1A1KDRRIPK1 | |
| SCHEMBL869570 | 0.76 | EIF2AK3 (0.85) | EIF2AK3EIF2AK1NPC1MAPTRAB9A | |
| SCHEMBL868562 | 0.76 | EIF2AK3 (0.72) | EIF2AK3EIF2AK1RIPK1 | |
| SCHEMBL868264 | 0.76 | EIF2AK3 (0.69) | EIF2AK3EIF2AK1RIPK1 | |
| SCHEMBL869562 | 0.76 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |