Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 12/20 | 0.61 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27975489 | 0.87 | EIF2AK3 (0.67) | EIF2AK3EIF2AK1KDRCYP11B1CYP11B2 | |
| SCHEMBL868669 | 0.86 | EIF2AK3 (0.68) | EIF2AK3EIF2AK1KDRCYP11B1CYP11B2 | |
| SCHEMBL2373601 | 0.85 | EIF2AK3 (0.61) | EIF2AK3EIF2AK1KDRNPC1MAPT | |
| SCHEMBL869060 | 0.83 | EIF2AK3 (0.43) | EIF2AK3EIF2AK1BRD4NPC1CYP1A2 | |
| SCHEMBL869335 | 0.82 | EIF2AK3 (0.66) | EIF2AK3EIF2AK1BRD4KDRNPC1 | |
| SCHEMBL869628 | 0.81 | EIF2AK3 (0.44) | EIF2AK3EIF2AK1KDRMPOCYP3A4 | |
| SCHEMBL869570 | 0.76 | EIF2AK3 (0.85) | EIF2AK3EIF2AK1NPC1MAPTRAB9A | |
| SCHEMBL868562 | 0.76 | EIF2AK3 (0.72) | EIF2AK3EIF2AK1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL868264 | 0.76 | EIF2AK3 (0.69) | EIF2AK3EIF2AK1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL869562 | 0.76 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| US-8598156-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-12-03 | — | — | US | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | EIF2AK3 16/4885EIF2AK1 20/4885BRD4 1064/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | EIF2AK3 16/4885EIF2AK1 20/4885BRD4 1064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.