Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 18/20 | 0.68 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | HCK | P08631 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869029 | 0.85 | RIPK1 (0.66) | RIPK1EIF2AK3PIK3CDABL1EGFR | |
| SCHEMBL870134 | 0.80 | RIPK1 (0.84) | RIPK1EIF2AK3 | |
| SCHEMBL868450 | 0.79 | RIPK1 (0.86) | RIPK1EIF2AK3 | |
| SCHEMBL869703 | 0.79 | RIPK1 (0.87) | RIPK1EIF2AK3 | |
| SCHEMBL869003 | 0.79 | RIPK1 (0.87) | RIPK1EIF2AK3 | |
| SCHEMBL869735 | 0.78 | RIPK1 (0.75) | RIPK1EIF2AK3 | |
| SCHEMBL868428 | 0.78 | RIPK1 (0.75) | RIPK1EIF2AK3 | |
| SCHEMBL868498 | 0.78 | EIF2AK3 (0.75) | RIPK1EIF2AK3 | |
| SCHEMBL868654 | 0.78 | EIF2AK3 (0.76) | RIPK1EIF2AK3 | |
| SCHEMBL867891 | 0.77 | EIF2AK3 (0.84) | RIPK1EIF2AK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |