Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 19/20 | 0.77 |
| ▸ | TACR2 | P21452 | 2/20 | 0.65 |
| ▸ | TACR3 | P29371 | 2/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.65 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373221 | 0.93 | TRPV4 (0.68) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL2373252 | 0.92 | TRPV4 (0.78) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL2373728 | 0.91 | TRPV4 (0.67) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL2373167 | 0.91 | TRPV4 (0.65) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| Hydrochloric Acid SCHEMBL2372824 | 0.91 | TRPV4 (0.80) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL2372024 | 0.90 | TRPV4 (0.65) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL2372858 | 0.90 | TRPV4 (0.64) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL6848917 | 0.89 | TACR3 (0.70) | TRPV4TACR2TACR3KCNH2 | |
| SCHEMBL2372501 | 0.88 | TRPV4 (0.62) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL2462356 | 0.88 | TRPV4 (0.64) | TRPV4TACR2TACR3KCNH2CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |