Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 5/20 | 0.45 |
| ▸ | NOS1 | P29475 | 5/20 | 0.45 |
| ▸ | NOS2 | P35228 | 5/20 | 0.45 |
| ▸ | HTR5A | P47898 | 3/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373669 | 1.00 | NOS3 (0.45) | NOS3NOS1NOS2HTR5AMMP1 | |
| SCHEMBL2373320 | 0.91 | NOS3 (0.42) | NOS3NOS1NOS2HTR5ANR1H4 | |
| SCHEMBL2373317 | 0.91 | NOS3 (0.42) | NOS3NOS1NOS2HTR5ANR1H4 | |
| SCHEMBL2376457 | 0.91 | PPARD (0.38) | NOS3NOS1NOS2HTR5AMMP1 | |
| SCHEMBL2376461 | 0.91 | PPARD (0.38) | NOS3NOS1NOS2HTR5AMMP1 | |
| SCHEMBL2374128 | 0.86 | NOS3 (0.44) | NOS3NOS1NOS2HTR5AMMP1 | |
| SCHEMBL2374123 | 0.86 | NOS3 (0.44) | NOS3NOS1NOS2HTR5AMMP1 | |
| SCHEMBL2375187 | 0.85 | NOS3 (0.46) | NOS3NOS1NOS2HTR5AMMP1 | |
| SCHEMBL2375181 | 0.85 | NOS3 (0.46) | NOS3NOS1NOS2HTR5AMMP1 | |
| SCHEMBL2375182 | 0.85 | NOS3 (0.46) | NOS3NOS1NOS2HTR5AMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110224210-A1 | NOVEL BIS-AMIDES AS ANTI-MALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224210-A1 | NOVEL BIS-AMIDES AS ANTI-MALARIAL AGENTS | CTSA, BECN1, HDAC6 | NOS3 783/4885NOS1 996/4885NOS2 548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.