Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | PTGFR | P43088 | 16/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372981 | 0.91 | DHODH (0.56) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2373268 | 0.91 | DHODH (0.49) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2372628 | 0.90 | DHODH (0.47) | DHODHPTGFRCYP3A4 | |
| SCHEMBL2373084 | 0.90 | DHODH (0.49) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2373064 | 0.90 | PTGFR (0.40) | PTGFRKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL2462371 | 0.87 | DHODH (0.44) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2372892 | 0.87 | DHODH (0.44) | DHODHPTGFRKDM4EMEN1KMT2A | |
| SCHEMBL2372055 | 0.85 | DHODH (0.54) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2372745 | 0.83 | PTGFR (0.61) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2372773 | 0.82 | DHODH (0.59) | DHODHPTGFRKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |