Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGFR | P43088 | 4/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 14/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373709 | 0.91 | TRPV4 (0.39) | PTGFRTRPV4TACR2TACR3KCNH2 | |
| SCHEMBL2373855 | 0.90 | DHODH (0.46) | PTGFRKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL2372311 | 0.89 | TRPV4 (0.40) | PTGFRTRPV4TACR2TACR3KCNH2 | |
| SCHEMBL2465453 | 0.88 | TRPV4 (0.38) | PTGFRTRPV4TACR2TACR3KCNH2 | |
| SCHEMBL2372179 | 0.84 | TRPV4 (0.62) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL2373306 | 0.83 | DHODH (0.51) | PTGFRTRPV4KDM4EMEN1ALDH1A1 | |
| SCHEMBL2372142 | 0.83 | CTSA (0.44) | PTGFRTRPV4MEN1ALDH1A1KMT2A | |
| SCHEMBL2372484 | 0.82 | CTSA (0.38) | PTGFRTRPV4TACR2TACR3KCNH2 | |
| SCHEMBL2372981 | 0.82 | DHODH (0.56) | PTGFRKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL2373078 | 0.82 | TRPV4 (0.42) | TRPV4TACR2TACR3KCNH2CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |