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SCHEMBL23739148

SCHEMBL23739148

CCCCCCC(=O)NOCc1ccc(NC(=O)C(CCCNC(N)=O)NC(=O)CNC(=O)CCCC(=O)C(C)C)cc1

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ SIRT2 Q8IXJ6 17/20 0.43
▸ SIRT1 Q96EB6 13/20 0.43
▸ SIRT3 Q9NTG7 6/20 0.41
▸ NPY1R P25929 1/20 0.38
▸ NPY2R P49146 1/20 0.38
▸ NPY4R P50391 1/20 0.38
▸ NPY5R Q15761 1/20 0.38
▸ GRIA1 P42261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23739192 0.93 SIRT2 (0.38) SIRT2SIRT1SIRT3NPY1RNPY2R
SCHEMBL20880212 0.92 SIRT2 (0.44) SIRT2SIRT1SIRT3GRIA1
SCHEMBL24115692 0.87 SIRT2 (0.37) SIRT2SIRT1SIRT3NPY1RNPY2R
SCHEMBL24253175 0.86 SIRT2 (0.41) SIRT2SIRT1SIRT3NPY1RNPY2R
SCHEMBL20880254 0.86 SIRT2 (0.39) SIRT2SIRT1SIRT3NPY1RNPY2R
SCHEMBL22214485 0.85 SIRT2 (0.46) SIRT2SIRT1SIRT3GRIA1
SCHEMBL19522514 0.83 NPY4R (0.42) SIRT2SIRT1SIRT3NPY1RNPY2R
SCHEMBL20015437 0.83 NPY5R (0.40) SIRT2SIRT1SIRT3NPY1RNPY2R
SCHEMBL19841675 0.83 NPY5R (0.39) SIRT2SIRT1SIRT3NPY1RNPY2R
SCHEMBL16646743 0.82 SIRT2 (0.43) SIRT2SIRT1SIRT3NPY1RNPY2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3925627-A1 DRUG-CONJUGATES AND USES THEREOF Concortis Biosystems, Corp (US) 2021-12-22 — — EP disclosed
EP-3590541-B1 DRUG-CONJUGATES AND USES THEREOF CONCORTIS BIOSYSTEMS CORP (US) 2021-08-11 — — EP disclosed