Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 14/20 | 0.60 |
| ▸ | EIF2AK3 | Q9NZJ5 | 6/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NEK4 | P51957 | 1/20 | 0.44 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.44 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427223 | 0.90 | RIPK1 (0.59) | RIPK1EIF2AK3NTRK1CYP1A2LCK | |
| SCHEMBL2373766 | 0.89 | EIF2AK3 (0.48) | RIPK1EIF2AK3EIF2AK2EIF2AK1 | |
| SCHEMBL2426841 | 0.81 | RIPK1 (0.58) | RIPK1EIF2AK3NTRK1CYP1A2LCK | |
| SCHEMBL16156134 | 0.77 | RIPK1 (0.60) | RIPK1EIF2AK3NTRK1CYP1A2LCK | |
| SCHEMBL23059993 | 0.76 | RIPK1 (0.61) | RIPK1EIF2AK3NTRK1CYP1A2LCK | |
| SCHEMBL29911570 | 0.76 | RIPK1 (0.61) | RIPK1EIF2AK3NTRK1CYP1A2LCK | |
| SCHEMBL869164 | 0.75 | EIF2AK3 (0.72) | RIPK1EIF2AK3NTRK1CYP1A2LCK | |
| SCHEMBL2389079 | 0.74 | EIF2AK3 (0.67) | RIPK1EIF2AK3NTRK1CYP1A2LCK | |
| SCHEMBL869448 | 0.72 | EIF2AK3 (1.00) | RIPK1EIF2AK3NTRK1CYP1A2LCK | |
| SCHEMBL13861464 | 0.71 | EIF2AK3 (0.85) | RIPK1EIF2AK3NTRK1CYP1A2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | claimed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | claimed |
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |