Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18097457 | 0.85 | PDE2A (0.39) | CYP19A1PDE2A | |
| SCHEMBL9621026 | 0.79 | TSHR (0.50) | GRIA4ATMGPR35TSHRNR1H4 | |
| SCHEMBL16156937 | 0.78 | AKT2 (0.45) | AKT1KCNH2LMNA | |
| SCHEMBL10034267 | 0.72 | KIF11 (0.57) | GRIA4CYP3A4CYP19A1TSHRKIF11 | |
| SCHEMBL4670006 | 0.71 | TSHR (0.42) | GRIA4TSHRNR1H4KCNH2LMNA | |
| SCHEMBL23739406 | 0.71 | ACACB (0.38) | AKT1PDE4D | |
| SCHEMBL23739492 | 0.71 | HAO1 (0.38) | CLK1HIPK2CLK4AKT1ESR2 | |
| SCHEMBL12711504 | 0.71 | MAPT (0.51) | TSHRNR1H4LMNA | |
| SCHEMBL5250226 | 0.71 | CLK1 (0.56) | CLK1CLK2CLK3DYRK1AHIPK1 | |
| SCHEMBL20348834 | 0.70 | KCNH2 (0.39) | AKT1PRKD3PRKCGPRKCBBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3285581-B1 | PYRAZOLYL PYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2021-08-11 | — | — | EP | disclosed |