Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18639818 | 0.87 | KDM4E (0.39) | ALOX15KDM4EALDH1A1POLBMAPT | |
| SCHEMBL18639836 | 0.87 | KDM4E (0.39) | ALOX15KDM4EALDH1A1POLBMAPT | |
| SCHEMBL18639839 | 0.87 | KDM4E (0.39) | ALOX15KDM4EALDH1A1POLBMAPT | |
| SCHEMBL18639819 | 0.85 | NPC1 (0.33) | ALOX15KDM4EALDH1A1POLBGAA | |
| SCHEMBL18666828 | 0.85 | NPC1 (0.33) | ALOX15KDM4EALDH1A1POLBGAA | |
| SCHEMBL18639837 | 0.85 | NPC1 (0.33) | ALOX15KDM4EALDH1A1POLBGAA | |
| SCHEMBL18639867 | 0.85 | NPC1 (0.33) | ALOX15KDM4EALDH1A1POLBGAA | |
| SCHEMBL7671030 | 0.83 | KDM4E (0.39) | ALOX15KDM4EALDH1A1POLBTP53 | |
| SCHEMBL25654057 | 0.82 | ALOX15 (0.31) | ALOX15KDM4EALDH1A1POLBMAPT | |
| SCHEMBL6368923 | 0.82 | KDM4E (0.37) | ALOX15KDM4EALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |