Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739521 | 0.95 | POLB (0.35) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL23739667 | 0.93 | POLB (0.35) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL24572202 | 0.91 | POLB (0.35) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL23739899 | 0.90 | POLB (0.34) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL23934426 | 0.87 | POLB (0.34) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL23739881 | 0.86 | S1PR5 (0.30) | — | |
| SCHEMBL23739656 | 0.84 | IDO1 (0.38) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL21658797 | 0.84 | MAPT (0.40) | POLBALDH1A1LMNATHRBMAPT | |
| SCHEMBL19310260 | 0.84 | POLB (0.48) | POLBALDH1A1LMNATHRBMAPT | |
| SCHEMBL23739877 | 0.82 | MAPT (0.38) | POLBALDH1A1LMNATHRBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |