Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739667 | 0.92 | POLB (0.35) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL23739521 | 0.91 | POLB (0.35) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL23739890 | 0.91 | POLB (0.35) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL23739899 | 0.90 | POLB (0.34) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL23934426 | 0.89 | POLB (0.34) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL21658797 | 0.85 | MAPT (0.40) | POLBALDH1A1LMNATHRBMAPT | |
| SCHEMBL19310260 | 0.85 | POLB (0.48) | POLBALDH1A1LMNATHRBMAPT | |
| SCHEMBL23739656 | 0.84 | IDO1 (0.38) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL19222234 | 0.84 | LMNA (0.37) | POLBALDH1A1LMNATHRBGAA | |
| SCHEMBL19309935 | 0.84 | CARM1 (0.41) | POLBALDH1A1LMNATHRBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023249968-A1 | BIFUNCTIONAL COMPOUNDS CONTAINING PYRIDO[2,3-DJPYRIMIDIN-7(8H)-ONE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY | NIKANG THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |
| WO-2022140472-A1 | COMPOUNDS FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEOSOME PATHWAY | NIKANG THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |